It is likely the first game to increase the difficulty based on one's skin color, and it is also one of the first games to allow players to take direct control of a transgender character. These unique character customization options should help South Park: The Fractured But Whole stand apart from the other RPGs.
When they select the gender of their character, players can even choose between playing as transgender or cisgender. It also embraces the idea of gender identity, with players able to play as a female character, even though they were forced to be a boy in the first game.
South Park: The Fractured But Whole's social commentary extends beyond racism.